Titre: Bone Marrow And its Transplantation
Publié sur: 29 Jul 2016
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Bone Marrow And its Transplantation
Often in clinical research or clinical trials we come across the term bone marrow transplant. In this article we would introduce bone marrow transplant and its application.
This is a process to substitute damaged bone marrow with healthy bone marrow stem cells.
What is bone marrow?
It is the soft, fatty tissue inside your bones which produces blood cells. Stem cells are undifferentiated cells in the bone marrow that give rise to all of the different blood cells.
Bone marrow transplants can be used for treating patients with:
Leukemia....a life-threatening blood cancers
Aplastic anemia....disease which result in bone marrow failure
other immune system or hereditary diseases
There are 3 types of bone marrow transplants:
A stem cell transplant is performed after completion of chemotherapy and radiation. The stem cells are passed through into bloodstream usually through a tube called a central venous catheter. The process is similar to a blood transfusion. The stem cells pass through the blood into the bone marrow. Mostly no surgery is required.
Donor stem cells are collected in 2 ways:
Bone marrow harvest
It might cause the following symptoms:
reduction in blood pressure
Headache & nausea
Shortness of breath
Several researches on transplant has led to increase the survival rates with time, which has led to more patients seeking for this treatment and getting benefited. For many diseases, bone marrow transplant is the only cure option at this time.
How successful the transplant is depends on:
The type of transplant
How well the donor's cells matches
What type of cancer or illness treated
Age and health
Type and dosage of chemotherapy or radiation therapy that has been given
Any complications that might arise
A bone marrow transplant may completely or partially cure the illness. If the transplant is a success, one can go back to most of their normal activities as soon as they feel well. Usually it takes up to 1 year to recover fully, depending on what complications occur.
Complications or failure of the bone marrow transplant can lead to death.
Why the Procedure is done?
A bone marrow transplant replaces bone marrow that is either damaged or has been destroyed (ablated) by chemotherapy or radiation. Physicians believe that for many cancers, the donor's white blood cells might attack any remaining cancer cells, very much like the white cells attack bacteria or viruses when fighting an infection.
A physician might recommend a bone marrow transplant under following concerns:
Certain cancers for example lymphoma, leukemia, myelodysplasia and multiple myeloma
A disease that affects the production of bone marrow cells, like aplastic anemia, congenital neutropenia, severe immune system illnesses, sickle cell anemia, and thalassemia
Undergone chemotherapy that destroyed the bone marrow
How a transplant works
An autologous transplant is used for treatment of cancer using very high doses of chemotherapy that damages the bone marrow as a side effect. The autologous blood cell types replace the damaged marrow. This is how such transplants are used to do away with certain types of cancers such as lymphoma.
An allogeneic transplant also treats blood cancer, and offers the advantage of utilising the donor’s immune system to recognize and kill the cancer cells. Allogeneic transplant is also used for treatment of some non-cancerous diseases like sickle cell anemia. In diseases besides cancer,the transplant substitutes defective marrow cells with the donor’s healthy ones.
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Bone Marrow Transplantation is a peer-reviewed medical journal covering transplantation of bone marrow in humans. It is published monthly by Nature Research. The scope of the journal includes stem cell biology, transplantation immunology, translational research, and clinical results of specific transplant protocols. Bone Marrow Transplantation is abstracted and indexed in BIOBASECurrent Awareness in Biological Sciences, BIOSIS, Current ContentsClinical Medicine, Current ContentsLife Sciences. What is Bone Marrow Transplant The spongy or flexible tissue that is present in the interior of bones is known as bone marrow. It is present in the is widely used for treating congenital bone marrow disorders and malignant haematological diseases. Today, over 350 centres in Europe are performing more than 18 000 bone marrow transplants a year. Centres may report their View. Show abstract. Allogeneic peripheral blood stem cell transplantation in patients with early-phase hematologic malignancy: A retrospective comparison of short-term outcome with bone marrow transplantation. Full-text available. Find bone marrow transplantation stock images in HD and millions of other royalty-free stock photos, illustrations and vectors in the Shutterstock collection. Thousands of new, high-quality pictures added every day. You're currently using an older browser and your experience may not be optimal. Please consider upgrading. Learn more. The term hematopoietic stem cell transplantation HSCT has completely replaced the most widespread bone marrow transplantation BMT. This semantic change is based on the fact that not only. Part of the Advances in Experimental Medicine and Biology book series AEMB, volume 741. This semantic change is based on the fact that not only hematopoietic stem cells with capacity for regenerating haematopoiesis and the immune system of the recipient are located in the BM. Over the past 40 years, bone marrow transplantation and hematopoietic stem cell transplantation have been used with increasing frequency to treat numerous malignant and nonmalignant diseases. PostWorld War II. Bone marrow transplantation has emerged as a major form of treatment for a broad range of human diseases. Marrow transplantation has many unique biologic features and its principles differ markedly from the transplantation of solid organs. Ad- vances in Bone marrow transplantation has emerged as a major form of treatment for a broad range of human diseases. Marrow transplantation has many unique biologic features and its principles differ markedly from the transplantation o. Bone marrow transplantation does not involve the transfer of a discrete anatomic organ, as occurs in other forms of transplantation,. In 1956 American physician E. Donnall Thomas performed the first successful syngeneic genetically identical bone marrow transplant between two humans. Autologous transplant involves harvesting stem cells from the patients bone marrow and storing these cells prior to therapy. After the patient has undergone therapy to destroy the cancer cells, the stem cells are injected into the bloodstream to speed recovery of the bone marrow. You might need a bone marrow transplant if your bone marrow stops working and does not produce enough healthy blood cells. Bone marrow transplants may use cells from your own body autologous transplant or from a donor allogeneic transplant. Products & Services. Its job is to produce blood cells. If your bone marrow isn't functioning properly because of cancer or another disease, you may receive a stem cell transplant. To prepare for a stem cell transplant, you receive chemotherapy to kill the diseased cells and malfunctioning bone marrow. Biology of Blood and Marrow Transplantation. 2017 doi: Jagasia MH, et al. bone marrow transplant. stem cell transplant. bone marrow operation. bone marrow donor. bone marrow donation. bone marrow. Best Match. Preparation for surgery or its completion. Physician decides about procedure based on laboratory analysis data. Bone marrow word cloud